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DMT is an indole alkaloid which found in a wide variety of plants and animals, including in some amounts within the human body. Similar to psilocin and psilocybin, DMT is a hallucinogenic tryptamine drug or member of the tryptamine family of hallucinogens. Among all the psychedelics, DMT has the simplest chemical structure. The molecular weight just slightly heavier than glucose, the simplest sugar the body consume for energy. For this reason, it can readily cross the blood-brain barrier by the way of active transport. Its chemical structure closely looks like  the melatonin as well as endogenous neurotransmitter serotonin, the “hormone of darkness.” Moreover, it has many structural analogs which are also psychedelic, includes 4-AcO-DMT, 5-MeO-DMT, 4-PO-DMT (psilocybin), and 5-HO-DMT (bufotenin),.

In pure form, DMT is a crystalline solid, white in colour that’s usually get as its fumarate salt. Given that no stereocenters snd no isomers found in the DMT molecule. It’s not soluble in water but soluble in organic solvenr and aqueous acids. Many extraction methods to get DMT utilize this characteristic.


How to get DMT? DMT is commonly extracted from available natural sources rather than synthetically synthesized. This is because the starting materials available is high. A large variety of plants contain DMT, but it is commonly extracted from either  Acacia confusa or Mimosa hostilis .

Using two different techniques DMT can be extracted from the plant material. The first is the base/acid extraction and the second method is the straight-to-base extraction. Due to its simplicity, we will overview the second method of extraction, which can be performed in the kitchen in just a couple of days. Initially, the procedure includes DMT extraction into an aqueous solution, then mixing DMT freebase in a nonpolar hydrocarbon solvent, and finally can be received the freebase as a solid once it completely precipitates under cold temperature.

Step1: Extract the DMT from the Plant Material

The first step, crumble the root bark of Acacia confusa or of Mimosa hostilis with a coffee grinder. Slowly dissolve sodium hydroxide (lye) in a glass jar filled with water, the process of making a highly alkaline solution having a pH of around 13. Then add crumbled root bark powder to the solution, shake it well, and let it sit for an hour. The lye physically crumbles or break down the bark and let the DMT to be exposed to the nonpolar solvent.

Remember to take precaution, because lye can cause chemical burns, use gloves for hands as well as use face and eye protection for this step.

Step 2: Addion of Nonpolar Solvent to the Base Solution

This step is to, recover DMT freebase in a nonpolar solvent by the addition of naphtha to the mixing glass or jar. swirls  it with gentle, then the mixture will discrete into nonpolar and polar (aqueous) layers, the latter of which floats and contains the DMT. Separate the layers using a pipette by putting the naphtha (top) layer to a collection jar. Three more times repeat this procedure, all time use a new collection jar, to completely extract the DMT from the base solution.

After all four collection jars are filled, Keep them to the freezer and leave them overnight. By choice, at this point, some individuals wash the nonpolar solution many times with dilute sodium carbonate, which will create an aqueous layer after that get discarded.

Step 3: Crystallize the DMT by Freezing

The freezing temperature will precipitate DMT crystals. Pour in every jar through coffee filter using funnel and collect them from the naphtha jars. Over an interval of 10 hours, the DMT crystals will dry on the coffee filters. The dried powder of DMT will be ready to smoke, but if an individual wants to purify further then recrystallization step with hot naphthato be followed.

Step 4: Recrystallization

Recrystallize the DMT by adding a small part of hot naptha to the powder from the foregoing step. Once the solution gets cool, move it to the refrigerator for a few hours, and then put it in the freezer. The refined DMT crystals will precipitate out, and with the help of coffee filter, it can be collected  and dried for use.


the Speeter-Anthony synthesis is among common synthetic routes for making DMT.

Step 1: Reaction of Indole with Oxalyl Chloride

First, slowly add the oxalyl chloride (which is highly reactive) to a solution of diethyl ether and indole. After regular stirring, the instant  product, indole oxalyl chloride, precipitates as it is cast  into a yellow crystalline solid.

Step 2: React Indole Oxalyl Chloride with Dimethylamine 

Next, dissolve dimethylamine in cold diethyl ether. React this solution with indole oxalyl chloride to convert to an amide. The amide precipitates as a white solid after vigorous stirring. Filter it and wash it with ether and water, and leave it to dry.

Step 3: Reduction of Amide with Lithium Aluminium Hydride to Configure the Amine

Combine the solid amide from the foregoing step to a solution of lithium aluminum hydride (ALH) which dissolved in tetrahydrofuran (THF). carbonyl groups of the amide react with ALH, and forms an immediate iminium ion that is convert to a tertiary amine.

Backflow this reaction mixture for about several hours, then allow it cool to room temperature. Add dioxane to destroy any excess hydride. From this reaction white precipitate forms, which is impure DMT. Filter this, then wash it with THF, and dry impure DMT with anhydrous magnesium sulfate.

Step 4: Configure the Salt and Recystallize the DMT

Dissolve the available impure DMT in hot petroleum ether, then allow it to cool to form the DMT crystals. After that  Air-dry these DMT crystals, then add to anhydrous hydrogen chloride and anhydrous diethyl ether to form the salt. Finally, again crystallize the crystals with benzene and methanol to get  N,N-dimethyltryptamine hydrochloride.


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